Immunogenicity of Ad26.COV2.S vaccine against SARS-CoV-2 variants in humans - Nature.com

Abstract

The Ad26.COV2.S vaccine^1–3 has demonstrated clinical efficacy against symptomatic COVID-19, including against the B.1.351 variant that is partially resistant to neutralizing antibodies¹. However, the immunogenicity of this vaccine in humans against SARS-CoV-2 variants of concern remains unclear. Here we report humoral and cellular immune responses from 20 Ad26.COV2.S vaccinated individuals from the COV1001 phase 1/2 clinical trial² against the original SARS-CoV-2 strain WA1/2020 as well as against the B.1.1.7, CAL.20C, P.1., and B.1.351 variants of concern. Ad26.COV2.S induced median pseudovirus neutralizing antibody titers that were 5.0- and 3.3-fold lower against the B.1.351 and P.1 variants, respectively, as compared with WA1/2020 on day 71 following vaccination. Median binding antibody titers were 2.9- and 2.7-fold lower against the B.1.351 and P.1 variants, respectively, as compared with WA1/2020. Antibody-dependent cellular phagocytosis, complement deposition, and NK cell activation responses were largely preserved against the B.1.351 variant. CD8 and CD4 T cell responses, including central and effector memory responses, were comparable among the WA1/2020, B.1.1.7, B.1.351, P.1, and CAL.20C variants. These data show that neutralizing antibody responses induced by Ad26.COV2.S were reduced against the B.1.351 and P.1 variants, but functional non-neutralizing antibody responses and T cell responses were largely preserved against SARS-CoV-2 variants. These findings have implications for vaccine protection against SARS-CoV-2 variants of concern.

Access options

Subscribe to Journal

Get full journal access for 1 year

199,00 €

only 3,90 € per issue

Subscribe

Tax calculation will be finalised during checkout.

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

Rent or Buy

All prices are NET prices.

Additional access options:

• Log in
• Access through your institution
• Learn about institutional subscriptions

Author information

Author notes

1. These authors contributed equally: Galit Alter, Jingyou Yu, Jinyan Liu, Abishek Chandrashekar, Erica N. Borducchi, Lisa H. Tostanoski, Katherine McMahan, Catherine Jacob-Dolan

Affiliations

1. Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA

   Galit Alter, Jingyou Yu, Jinyan Liu, Abishek Chandrashekar, Erica N. Borducchi, Lisa H. Tostanoski, Katherine McMahan, Catherine Jacob-Dolan, Aiquan Chang, Tochi Anioke, Michelle Lifton, Joseph Nkolola, Kathryn E. Stephenson & Dan H. Barouch

2. Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA

   Galit Alter, Caroline Atyeo, Sally Shin & Dan H. Barouch

3. Harvard Medical School, Boston, MA, USA

   Catherine Jacob-Dolan, Aiquan Chang, Caroline Atyeo & Dan H. Barouch

4. University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

   David R. Martinez & Ralph S. Baric

5. Adaptive Biotechnologies, Seattle, WA, USA

   Paul Fields, Ian Kaplan & Harlan Robins

6. Icahn School of Medicine at Mount Sinai, New York, NY, USA

   Fatima Amanat & Florian Krammer

7. Janssen Vaccines & Prevention, Leiden, The Netherlands

   Mathieu Le Gars, Jerald Sadoff, Anne Marit de Groot, Macaya Douoguih, Johan van Hoof & Hanneke Schuitemaker

8. Janssen Research & Development, Beerse, Belgium

   Dirk Heerwegh & Frank Struyf

Authors

1. Galit Alter
   View author publications

   You can also search for this author in PubMed Google Scholar

2. Jingyou Yu
   View author publications

   You can also search for this author in PubMed Google Scholar

3. Jinyan Liu
   View author publications

   You can also search for this author in PubMed Google Scholar

4. Abishek Chandrashekar
   View author publications

   You can also search for this author in PubMed Google Scholar

5. Erica N. Borducchi
   View author publications

   You can also search for this author in PubMed Google Scholar

6. Lisa H. Tostanoski
   View author publications

   You can also search for this author in PubMed Google Scholar

7. Katherine McMahan
   View author publications

   You can also search for this author in PubMed Google Scholar

8. Catherine Jacob-Dolan
   View author publications

   You can also search for this author in PubMed Google Scholar

9. David R. Martinez
   View author publications

   You can also search for this author in PubMed Google Scholar

10. Aiquan Chang
    View author publications

    You can also search for this author in PubMed Google Scholar

11. Tochi Anioke
    View author publications

    You can also search for this author in PubMed Google Scholar

12. Michelle Lifton
    View author publications

    You can also search for this author in PubMed Google Scholar

13. Joseph Nkolola
    View author publications

    You can also search for this author in PubMed Google Scholar

14. Kathryn E. Stephenson
    View author publications

    You can also search for this author in PubMed Google Scholar

15. Caroline Atyeo
    View author publications

    You can also search for this author in PubMed Google Scholar

16. Sally Shin
    View author publications

    You can also search for this author in PubMed Google Scholar

17. Paul Fields
    View author publications

    You can also search for this author in PubMed Google Scholar

18. Ian Kaplan
    View author publications

    You can also search for this author in PubMed Google Scholar

19. Harlan Robins
    View author publications

    You can also search for this author in PubMed Google Scholar

20. Fatima Amanat
    View author publications

    You can also search for this author in PubMed Google Scholar

21. Florian Krammer
    View author publications

    You can also search for this author in PubMed Google Scholar

22. Ralph S. Baric
    View author publications

    You can also search for this author in PubMed Google Scholar

23. Mathieu Le Gars
    View author publications

    You can also search for this author in PubMed Google Scholar

24. Jerald Sadoff
    View author publications

    You can also search for this author in PubMed Google Scholar

25. Anne Marit de Groot
    View author publications

    You can also search for this author in PubMed Google Scholar

26. Dirk Heerwegh
    View author publications

    You can also search for this author in PubMed Google Scholar

27. Frank Struyf
    View author publications

    You can also search for this author in PubMed Google Scholar

28. Macaya Douoguih
    View author publications

    You can also search for this author in PubMed Google Scholar

29. Johan van Hoof
    View author publications

    You can also search for this author in PubMed Google Scholar

30. Hanneke Schuitemaker
    View author publications

    You can also search for this author in PubMed Google Scholar

31. Dan H. Barouch
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Dan H. Barouch.

Supplementary information

Reporting Summary

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Alter, G., Yu, J., Liu, J. et al. Immunogenicity of Ad26.COV2.S vaccine against SARS-CoV-2 variants in humans. Nature (2021). https://ift.tt/3x6U1gO

Download citation

• Received: 15 April 2021

• Accepted: 01 June 2021

• Published: 09 June 2021

• DOI: https://doi.org/10.1038/s41586-021-03681-2

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Adblock test (Why?)

Article From & Read More ( Immunogenicity of Ad26.COV2.S vaccine against SARS-CoV-2 variants in humans - Nature.com )
https://ift.tt/355rTyx
Health

Bagikan Berita Ini